Youth Mike Person Jersey , the 49ers are looking to defeat another lowly opponent — the New York Giants. The Giants enter this contest at 1-7, while the 49ers are slightly ahead at 2-7, so I fully expect a barn burner on Monday Night Football. Many expected New York to be a lot better under new head coach Pat Shurmur, with the addition of running back Saquon Barkley and with the return of a healthy wideout Odell Beckham Jr. However, the Giants have been inept so far this season, struggling to score on offense and stop opposing teams on defense. In comes second-year quarterback Nick Mullens, who impressed 49ers’ coaches and fans with his play on Thursday Night Football against the Raiders.The 49ers will be without linebacker Reuben Foster (hamstring), wideout Pierre Gar莽on (knee) and safety Jaquiski Tartt (shoulder) on Monday, so the challenge of a second-straight victory only gets more difficult. Here are some keys for another home victory over the Giants. 1. Slow down the Giants’ superstars, RB Saquon Barkley and WR Odell Beckham JrNew York is going to go as far as Barkley and Beckham Jr. take them this season. By far, they are the two best players on the roster and will need to be highly impressive week in and week out for the Giants to even have a chance against their opponents.Barkley is a true dual-threat running back, gaining at least 100 yards from scrimmage in every game. The former Penn State tailback has two 100-yard rushing games, but also has three games of nine receptions and one game with 14 catches.The Giants use Barkley in multiple looks and line him up all over the formation. Without Foster or Tartt on Monday, the challenge is going to fall squarely on rookie linebacker Fred Warner’s shoulders to cover Barkley in space. On the outside, Beckham Jr. is likely going to present major challenges to corners Richard Sherman and Ahkello Witherspoon on Monday. One of the best wideouts in the NFL, Beckham Jr. hasn’t had as productive of a season, primarily due to quarterback Eli Manning’s struggles.This season, Beckham Jr. has caught 61 passes for 785 yards, well on pace to break his career highs, but he’s only caught two touchdowns so far this season. During his first three years, he caught 12 Youth Adrian Colbert Jersey , 13 and 10 touchdowns respectively, but isn’t on pace to reach those numbers this season.If the 49ers can take both of these players out of their rhythm on Monday — an extremely difficult challenge — the changes of a win increase exponentially.2. QB Nick Mullens continues his “Mullens’ Magic” from last weekThe biggest difference in the 49ers’ win and losses since quarterback Jimmy Garoppolo got injured was the quarterback play. C.J. Beathard was very tentative and playing scared, while Mullens was confident and moved the offense up and down the field.Now that Mullens has tasted some success in the NFL, his biggest challenge lies ahead of him: sustaining that level of play for multiple games. We’re also about to find out if Mullens and the 49ers’ offense is really that productive or the Raiders’ defense is that pathetic.After having an efficient game, Mullens will need to continue that theme on Monday. His pre-snap reads against the Raiders were spot-on, allowing him to make quick decisions and get rid of the ball immediately.The Giants’ passing defense should be much better than the Raiders’, as they’re ranked 13th in terms of yards per attempt (7.4). New York also employs more talent in the back end of that defense, primarily spear-headed by former Alabama standout Landon Collins.If Mullens can manage to protect the ball, make safe throws and hit the occasional home run, the 49ers’ offense should be able to score enough to overcome the Giants.3. DC Robert Saleh should turn the pass rushers loose against the Giants’ OLThrough eight weeks, the Giants have given up 31 sacks, a lot of them due to quarterback Eli Manning’s inability to move around in the pocket. New York doesn’t have the greatest offensive line, but when the quarterback’s mobility is limited, it becomes that much more difficult to avoid sacks. With the return of linebacker Dekoda Watson last week, adding to linebacker Cassius Marsh and defensive lineman DeForest Buckner, the 49ers should pressure the heck out of Manning in obvious passing situations.Opposing defenses have had a lot of success bringing the blitz against the Giants and I don’t expect the 49ers to do anything different on Monday night. The Kansas City Chiefs are on an upward trajectory, their blistering start spearheaded by a young, transcendent quarterback in Patrick Mahomes who is already setting NFL records.The San Francisco 49ers are the opposite in every way.Not only were they soundly beaten in a 38-27 loss at Arrowhead Stadium on Sunday, trailing at one point by four touchdowns, they also lost their own franchise quarterback when Jimmy Garoppolo was carted off in the closing minutes with what appears to be a season-ending knee injury.49ers coach Kyle Shanahan said the team will know more Monday, when Garoppolo has another round of tests in San Francisco. But he acknowledged late Sunday that the injury appears to be an ACL."Any time you lose your starting quarterback http://www.49erscheapstore.com/joe-staley-jersey-cheap ," Shanahan said, "that's a big deal."The 49ers (1-2) signed Garoppolo to a five-year, $137.5 million contract earlier this year after he led them to five consecutive wins to cap last season. And despite some turnover problems the first two weeks he had been pretty good, throwing a pair of touchdown passes against Kansas City.Everything turned in the fourth quarter, though, when Garoppolo scrambled toward the sideline. His left knee buckled as he cut back, rather than step safely out of bounds, and Chiefs cornerback Steven Nelson delivered a wicked shoulder-to-shoulder shot for good measure.C.J. Beathard wound up entering the game, threw a touchdown pass that was wiped out by offensive pass interference, and never got to take another snap as the Chiefs put the game away.His next snap will probably be the first one next week against the Chargers."It' definitely a blow. He's a great quarterback and obviously a great leader," said Beathard, who started five games last season before Garoppolo arrived in a trade with New England."Just keep these guys together. Keep leading them," he said. "We had a lot of injuries today, not just Jimmy. A lot of guys went down today. Just a matter of keeping everybody healthy next week."Meanwhile, the Chiefs (3-0) couldn't be happier with the performance of their young quarterback.Mahomes threw for 314 yards and three touchdowns against San Francisco, giving him 13 on the year without an interception. That broke Peyton Manning's NFL record for the first three weeks of a season.Perhaps most impressive, though, was the way Mahomes spread the wealth. He targeted 11 different receivers, connected with eight and found three with touchdown throws."Pat lives for these moments," said Chiefs wide receiver Chris Conley, who had one of the TDs. "I think he excels when the lights are on http://www.the49ersfootballauthentic.com/k_waun-williams-jersey-authentic , and in front of big crowds. I think he's right at home. I think he's in his element. I think he's still growing into his role as the starting quarterback here, and we've just got to keep working with him and growing as well."As the 49ers and Chiefs roll into next week, here are five takeaways from Sunday:PENALTY PROBLEMS: The 49ers were whistled for 14 penalties for 147 yards, and that doesn't count a couple instances of off-setting flags and where they were penalized twice on the same play. That yardage total is substantial chunk of the 408 yards of total offense managed by San Francisco.SACK ATTACK: The Chiefs only had two sacks through the first two weeks, but Justin Houston had two by himself on Sunday. Dee Ford also had a sack before leaving with a groin injury, and Allen Bailey had another to help stop San Francisco's final drive of the game.RUN, RUN, RUN: San Francisco rallied on the legs of Matt Breida, who led the NFL in rushing coming into the game and had 90 yards on 10 carries, and Alfred Morris, who had 14 carries for 67 yards and a touchdown. With uncertainty at quarterback, the 49ers' ground game will be even more important.SPEAKING OF RUN: Chiefs running back Kareem Hunt, last year's rushing champ, had his first two TD runs this season. He only gained 44 yards on 18 carries against San Francisco, but many of them came in the closing minutes, when he picked up two first downs to put the game away.MORE INJURY NEWS: The 49ers lost cornerback Richard Sherman to a calf injury, safety Adrian Colbert to an ankle injury, linebacker Reuben Foster on a tackle and backup defensive back Tarvarius Moore to a wrist injury. Throw in a shoulder injury to safety Jaquiski Tartt that kept him on the inactive list and San Francisco has plenty of injury problems on defense.